A confraternity charged with caring for the church of Santa Lucia del Gonfalone built this palazzo around 1600, on Rome’s Via Giulia, at the same time the New Prisons went up directly across the street. The building’s inscription, D.O.M., stands for Deo Optimo Maximo, to God, best and greatest, a phrase borrowed from the neighboring church. Architect Marco David restored both church and palazzo in 1764, and further renovations came a century later under architect Francesco Azzurri, who moved marble flooring from the church into the palazzo during that work.
The Carthusian order acquired the building in 1912, and the Claretian Missionaries later bought it and converted it into a monastery. In 1968, a private company took over the property, turning it into offices that the Italian Ministry of Justice rented until 2009. It reopened as a boutique hotel afterward, keeping much of its Renaissance-era structure intact beneath a moody, contemporary redesign.